Dottorato in Scienze Farmaceutiche e Biomolecolari

Selected research products

PEER-REVIEWED ORIGINAL PUBLICATIONS

Boscaro V, Rivoira M, Sgorbini B, Bordano V, Dadone F, Gallicchio M, Pons A, Benetti E, Rosa AC. Evidence-Based Anti-Diabetic Properties of Plant from the Occitan Valleys of the Piedmont Alps. Pharmaceutics. 2022 Nov 3;14(11):2371.  doi: 10.3390/pharmaceutics14112371.

Bordano V, Kinsella GK, Cannito S, Dianzani C, Gigliotti CL, Stephens JC, Monge C, Bocca C, Rosa AC, Miglio G, Dianzani U, Findlay JBC, Benetti E. G protein-coupled receptor 21 in macrophages: An in vitro study. Eur J Pharmacol. 2022 Jul 5; 926:175018. doi: 10.1016/j.ejphar.2022.175018. Epub 2022 May 7.

Rosa AC, Nardini P, Sgambellone S, Gurrieri M, Spampinato SF, Dell’Accio A, Chazot PL, Obara I, Liu WL, Pini A. CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms. Biomolecules. 2022; 12(2):184. https://doi.org/10.3390/biom12020184

Verta R, Gurrieri M, Borga S, Benetti E, Pollicino P, Cavalli R, Thurmond RL, Chazot PL, Pini A, Rosa AC, Grange C. The interplay between histamine h4 receptor and the kidney function: The lesson from h4 receptor knockout mice. Biomolecules. 2021 Oct 15;11(10):1517. doi: 10.3390/biom11101517

Kinsella GK, Cannito S, Bordano V, Stephens JC, Rosa AC, Miglio G, Guaschino V, Iannaccone V, Findlay JBC, Benetti E. GPR21 inhibition increases glucose-uptake in HepG2 cells. Int J Mol Sci. 2021 Oct 5;22(19):10784. doi: 10.3390/ijms221910784.

Rosa AC, Corsi D, Cavi N, Bruni N, Dosio F. Superoxide dismutase administration: A review of proposed human uses. Molecules. 2021 Mar 25;26(7):1844. doi: 10.3390/molecules26071844.

Rosa AC, Bruni N, Meineri G, Corsi D, Cavi N, Gastaldi D, Dosio F. Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approachesInt J Biol Macromol. 2021 Jan 31;168:846-865. doi: 10.1016/j.ijbiomac.2020.11.149.

Pini A, Fazi C, Nardini P, Calvani M, Fabbri S, Guerrini A, Forni G, La Marca G, Rosa AC, Filippi L. Effect of Beta 3 Adrenoreceptor Modulation on Patency of the Ductus Arteriosus. Cells. 2020 Dec 7;9(12):2625.  doi: 10.3390/cells9122625

Appleton SL, Tannous M, Argenziano M, Muntoni E, Rosa AC, Rossi D, Caldera F, Scomparin A, Trotta F, Cavalli R. Nanosponges as protein delivery systems: Insulin, a case study. Int J Pharm. 2020 Nov 30;590:119888. doi: 10.1016/j.ijpharm.2020.119888.

Rosa AC, Mio M, Andreadou I, Sumbayev VV. Editorial: The Challenge of New Therapeutic Approaches for Unmet Therapeutic Needs. Front Pharmacol. 2020 Sep 30;11:01341. doi: 10.3389/fphar.2020.01341.

Benetti E, Liberto E, Bressanello D, Bordano V, Rosa AC, Miglio G, Haxhi J, Pugliese G, Balducci S, Cordero C. Sedentariness and Urinary Metabolite Profile in Type 2 Diabetic Patients, a Cross-Sectional Study. Metabolites. 2020 May 18;10(5):205.  doi: 10.3390/metabo10050205.

Grange C*, Gurrieri M*, Verta R, Fantozzi R, Pini A, Rosa AC. Histamine in the kidneys: what is its the role in renal pathophysiology? Br J Pharmacol 2020;177(3):503‐515. doi:10.1111/bph.14619

Cucci MA, Compagnone A, Daga M, Grattarola M, Ullio C, Roetto A, Palmieri A, Rosa AC, Argenziano M, Cavalli R, Simile MM, Pascale RM, Dianzani C, Barrera G, Pizzimenti S. Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells. Free Radic Biol Med. 2019 Sep;141:205-219. doi: 10.1016/j.freeradbiomed.2019.06.009.

Verta R, Grange C, Gurrieri M, Borga S, Nardini P, Argenziano M, Ghè C, Cavalli R, Benetti E, Miglio G, Bussolati B, Pini A, Rosa AC. Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice. Int J Mol Sci. 2019 May 24;20(10). pii: E2554. doi: 10.3390/ijms20102554.

Pini A, Verta R, Grange C, Gurrieri M, Rosa AC. Histamine and diabetic nephropathy: an up today overview. Clin Sci (Lond). 2019 Jan 3;133(1):41-54. doi: 10.1042/CS20180839

Rosa AC, Benetti E, Gallicchio M, Boscaro V, Cangemi L, Dianzani C, Miglio G. Analyzing Cysteine Site Neighbors in Proteins to Reveal Dimethyl Fumarate Targets. Proteomics. 2019 Jan 11:e1800301. doi: 10.1002/pmic.201800301.

Pini A, Grange C, Veglia E, Argenziano M, Cavalli R, Guasti D, Calosi L, Ghè C, Solarino R, Thurmond RL, Camussi G, Chazot PL, Rosa AC. Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice. Pharmacol Res. 2018 Feb;128:18-28. doi: 10.1016/j.phrs.2018.01.002. Epub 2018 Jan 6.

Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, Della Pepa C, Canaparo R, Serpe L. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol. 2017 Jun 21;23(23):4200-4210. doi: 10.3748/wjg.v23.i23.4200.

Veglia E*, Pini A*, Moggio A, Grange C, Premoselli F, Miglio G, Tiligada K, Fantozzi R, Chazot PL, Rosa AC. Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity. Pharmacol Res. 2016 Dec;114:27-38. doi: 10.1016/j.phrs.2016.10.011. Epub 2016 Oct 14.

Lucarini L*, Pini A*, Rosa AC, Lanzi C, Durante M, Chazot PL, Krief S, Schreeb A, Stark H, Masini E. Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis. Pharmacol Res. 2016 Sep;111:740-8. doi:10.1016/j.phrs.2016.07.037. Epub 2016 Jul 27. PubMed PMID: 27475884.

Pini A, Obara I, Battell E, Chazot PL, Rosa AC. Histamine in diabetes: Is it time to reconsider? Pharmacol Res. 2016 Sep;111:316-24. doi:10.1016/j.phrs.2016.06.021. Epub 2016 Jun 22. PubMed PMID: 27343700.

Pini A*, Chazot PL*, Veglia E, Moggio A, Rosa AC. H3 receptor renal expression in normal and diabetic rats. Inflamm Res. 2015 May;64(5):271-3. doi:10.1007/s00011-015-0808-y. Epub 2015 Mar 7. PubMed PMID: 25745947.

Veglia E, Grange C, Pini A, Moggio A, Lanzi C, Camussi G, Chazot PL, Rosa AC. Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflamm Res. 2015 Apr;64(3-4):261-70. 

Rosa AC, Pini A, Lucarini L, Lanzi C, Veglia E, Thurmond RL, Stark H, Masini E. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. doi: 10.1124/jpet.114.215152. Epub 2014 Sep 2. PubMed PMID: 25185215.

Collino M, Rogazzo M, Pini A, Benetti E, Rosa AC, Chiazza F, Fantozzi R, Bani D, Masini E. Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury. J Cell Mol Med. 2013 Nov;17(11):1494-505. doi:10.1111/jcmm.12120. Epub 2013 Sep 20. PubMed PMID: 24079335; PubMed Central PMCID: PMC4117562.

Rosa AC, Fantozzi R. The role of histamine in neurogenic inflammation. Br J Pharmacol. 2013 Sep;170(1):38-45. doi: 10.1111/bph.12266. Review. PubMed PMID: 23734637; PubMed Central PMCID: PMC3764847.

Collino M, Rogazzo M, Pini A, Benetti E, Rosa AC, Fantozzi R, Bani D, Masini E. Acute treatment with relaxin attenuates the injury/dysfunction induced by renal ischemia/reperfusion injury. Ital J Anat Embryol. 2013;118(1 Suppl):74-6. PubMed PMID: 24640578.

Rosa AC, Grange C, Pini A, Katebe MA, Benetti E, Collino M, Miglio G, Bani D, Camussi G, Chazot PL, Fantozzi R. Overexpression of histamine H4 receptors in the kidney of diabetic rat. Inflamm Res. 2013 Apr;62(4):357-65. doi:10.1007/s00011-012-0587-7. Epub 2012 Dec 22.

Mondovi B, Fogel WA, Federico R, Calinescu C, Mateescu MA, Rosa AC, Masini E. Effects of amine oxidases in allergic and histamine-mediated conditions. Recent Pat Inflamm Allergy Drug Discov. 2013 Jan 1;7(1):20-34. Review. PubMed PMID: 22946464.

Miglio G, Rosa AC, Rattazzi L, Grange C, Camussi G, Fantozzi R. Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action. Br J Pharmacol. 2012 Oct;167(3):641-53. doi: 10.1111/j.1476-5381.2012.02026.x. PubMed PMID: 22594945; PubMed Central PMCID: PMC3449267.

Rosa AC, Rattazzi L, Miglio G, Collino M, Fantozzi R. Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes. Inflamm Res. 2012 Apr;61(4):311-7. doi: 10.1007/s00011-011-0412-8. Epub 2012 Jan 6. PubMed PMID: 22223068. IF 2,14 citation number (self-citation excluded): 5

Minelli R, Serpe L, Pettazzoni P, Minero V, Barrera G, Gigliotti C, Mesturini R, Rosa AC, Gasco P, Vivenza N, Muntoni E, Fantozzi R, Dianzani U, Zara GP, Dianzani C. Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells. Br J Pharmacol. 2012 May;166(2):587-601. doi: 10.1111/j.1476-5381.2011.01768.x. PubMed PMID: 22049973; PubMed Central PMCID: PMC3417491.  

Collino M, Benetti E, Miglio G, Castiglia S, Rosa AC, Aragno M, Thiemermann C, Fantozzi R. Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. Free Radic Biol Med. 2011 Jan 15;50(2):345-53. doi: 10.1016/j.freeradbiomed.2010.10.710. Epub 2010 Nov 1. PubMed PMID: 21047550.

Miglio G, Rosa AC, Rattazzi L, Grange C, Collino M, Camussi G, Fantozzi R. The subtypes of peroxisome proliferator-activated receptors expressed by human podocytes and their role in decreasing podocyte injury. Br J Pharmacol. 2011 Jan;162(1):111-25. doi: 10.1111/j.1476-5381.2010.01032.x. PubMed PMID: 20840470; PubMed Central PMCID: PMC3012410.

Miglio G, Rosa AC, Rattazzi L, Collino M, Lombardi G, Fantozzi R. PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. Neurochem Int. 2009 Dec;55(7):496-504. doi: 10.1016/j.neuint.2009.05.001. Epub 2009 May 13. PubMed PMID: 19442697.

Miglio G, Rattazzi L, Rosa AC, Fantozzi R. PPARgamma stimulation promotes neurite outgrowth in SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2009 Apr 24;454(2):134-8. doi: 10.1016/j.neulet.2009.03.014. Epub 2009 Mar 11. PubMedPMID: 19429070.

Gallicchio M, Benetti E, Rosa AC, Fantozzi R. Tachykinin receptor modulation of cyclooxygenase-2 expression in human polymorphonuclear leucocytes. Br J Pharmacol. 2009 Feb;156(3):486-96. doi: 10.1111/j.1476-5381.2008.00033.x. Epub 2009 Jan 16. PubMed PMID: 19154444; PubMed Central PMCID: PMC2697683.

Gallicchio M, Benetti E, Rosa AC, Fantozzi R. Substance P-induced cycloxygenase-2 expression in polymorphonuclear cells. Inflamm Res. 2008;57 Suppl 1:S17-8. doi: 10.1007/s00011-007-0608-0. PubMed PMID: 18345509.

Gallicchio M, Rosa AC, Dianzani C, Brucato L, Benetti E, Collino M, Fantozzi R. Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). Br J Pharmacol. 2008 Mar;153(5):870-8. Epub 2007 Dec 17. PubMed PMID: 18084318; PubMed Central PMCID: PMC2267284.

Dianzani C, Brucato L, Gallicchio M, Rosa AC, Collino M, Fantozzi R. Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression. Br J Pharmacol. 2008 Mar;153(6):1153-61. Epub 2007 Dec 17. PubMed PMID: 18084316; PubMed Central PMCID: PMC2275462.

Gallicchio M, Rosa AC, Benetti E, Collino M, Dianzani C, Fantozzi R. Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. Br J Pharmacol. 2006 Mar;147(6):681-9. PubMed PMID: 16432508; PubMed Central PMCID: PMC1751347.

Collino M, Aragno M, Mastrocola R, Gallicchio M, Rosa AC, Dianzani C, Danni O, Thiemermann C, Fantozzi R. Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol. 2006 Jan 13;530(1-2):70-80. Epub 2005 Dec 28. PubMed PMID: 16386242.

BOOK CHAPTERS

Pini A, Veglia E, Rosa AC. (2017) Histamine and the Kidney: In Vivo Animal Models. In: Tiligada E, Ennis M. (eds) Histamine Receptors as Drug Targets. Methods in Pharmacology and Toxicology. Humana Press, New York, NY

Pini A, Veglia E, Grange C, Rosa AC. (2017) Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy. In: Tiligada E, Ennis M. (eds) Histamine Receptors as Drug Targets. Methods in Pharmacology and Toxicology. Humana Press, New York, NY

 

Courses

• FARMACOLOGIA SPERIMENTALE (STF0253)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Farmacologia I - D.M. 270/04 - (Canale C) (MED3034D)
  Corso di Laurea in Infermieristica - A.O.U. Città della Salute e della Scienza di Torino
• Farmacologia II - D.M. 270/04 - (Canale C) (SSP0378B)
  Corso di Laurea in Infermieristica - A.O.U. Città della Salute e della Scienza di Torino
• Infermieristica clinica generale (Canale C) - D.M. 270/04 - (MED3034)
  Corso di Laurea in Infermieristica - A.O.U. Città della Salute e della Scienza di Torino
• Infermieristica clinica in area medica (Canale C) - D.M. 270/04 - (SSP0378)
  Corso di Laurea in Infermieristica - A.O.U. Città della Salute e della Scienza di Torino
• TIROCINIO di FARMACOLOGIA DEGLI AUTACOIDI (SME0908)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
• Tossicologia (CTF) (FAR0032)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Tossicologia e farmacovigilanza (Farmacia) (STF0056)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche

Research topics

MAJOR COLLABORATIONS

Dr. PL Chazot, Topic: histamine in diabetic nephropahty, School of Biological and Biomedical Sciences and Wolfson Research Institute, Durham University, UK

Dr. A. Pini, Topics: histamine in diabetic nephropathy and in lung fibrosis, new ocular formulation for corneal disease, Dept. Clinical and Experimental Medicine, Anatomy and histology section, University of Florence, Italy

Prof. G. Camussi and Dr. C. Grange, Topic: diabetic nephropathy models, Dept. Medical Science, University of Turin, Italy

Dr. R.L. Thurmond, Topic: histamine in diabetic nephropahty, Janssen Reasearch and Development, LLC, USA.

Dr. S. Liu, Topic: histamine H₃R receptor in diabetes complications, Ziarco Pharma, US

Prof. E. Masini, Topic: histamine and lung fibrosis, Dept. NEUROFARBA, Pharmacology Section,

 University of Florence, Italy

Prof. M. Ennis, Topic: lung diseases, School of Medicine, Dentistry and Biomedical Sciences and Centre for Infection and Immunity, Queen’s University, Belfast, UK

Dr. L Filippi, Topic: New ocular formulation for corneal disease, Terapia Intensiva Neonatale, Azienda Ospedaliera Universitaria Meyer, Florence, Italy

Prof. R. Cavalli, Topic: New ocular formulation for corneal disease and development of in vitro model to assess drug oral bioavailability; Dept. of Scienza e Tecnologia del Farmaco, University of Turin, Italy

Research groups

• Farmacologia degli autacoidi

Research projects

• GPR21: a new target for type 2 diabetes therapy?
• Evaluation of the efficacy o anti-H1 antihistamine drug(s) for diabetic nephroapthy
• H4 Histamine Receptor As A New Pharmacological Target For The Treatment Of Diabetic Nephropathy (HISDIAN)

Academic bodies

• Consiglio di Dipartimento

• Commissione Monitoraggio e Riesame del Corso di laurea in Farmacia

Office hours

Non è previsto un giorno specifico di ricevitemtno, ma gli studenti possono concordare via email modalità, data e orario di ricevimento. Per gli studenti che ne abbiano la necessità è possible anche concordare un colloquio da remoto via webex